The proportion of endometrial tumours associated with Lynch syndrome (PETALS): A prospective cross-sectional study

202095 citationsJournal Articlegold Open Access

Authors

Neil Ryan · University of Manchester

R F McMahon · Manchester Academic Health Science Centre

Simon Tobi · Manchester Academic Health Science Centre

Tristan Snowsill · University of Exeter

Shona Esquibel · Manchester Academic Health Science Centre

Andrew J. Wallace · Manchester Academic Health Science Centre

Sancha Bunstone

Abstract

In this study, we observed that age, family history, and histology are imprecise clinical correlates of LS-EC. IHC outperformed MSI for tumour triage and reliably identified both germline and somatic MMR mutations. The 3.2% proportion of LS-EC is similar to colorectal cancer, supporting unselected screening of EC for LS.

Topics & Keywords

Genetic factors in colorectal cancer Cancer Genomics and Diagnostics Colorectal and Anal Carcinomas

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 17, Issue 9, pp. e1003263-e1003263

DOI: 10.1371/journal.pmed.1003263

Field-Weighted Citation Impact: 8.56