The Prophylactic Effect of Pinocembrin Against Doxorubicin-Induced Cardiotoxicity in an In Vitro H9c2 Cell Model

202036 citationsJournal Articlegold Open Access

Authors

Nonhlakanipho F. Sangweni · Stellenbosch University

Malebogo M. Moremane · Stellenbosch University

Sylvia Riedel · South African Medical Research Council

Derick van Vuuren · Stellenbosch University

Barbara Huisamen · Stellenbosch University

Lawrence Mabasa · South African Medical Research Council

Reenen Barry

Abstract

The findings presented in this study showed, for the first time, that Pin attenuates Dox-induced cardiotoxicity without reducing its chemotherapeutic effect. We propose that additional studies, using in vivo models, should be conducted to further investigate Pin as a suitable candidate in the prevention of the cardiovascular dysfunction inferred by Dox administration.

Topics & Keywords

Chemotherapy-induced cardiotoxicity and mitigation Cancer Treatment and Pharmacology Carbon Nanotubes in Composites

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Pharmacology

Volume 11, pp. 1172-1172

DOI: 10.3389/fphar.2020.01172

Field-Weighted Citation Impact: 3.90