The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice

2020142 citationsJournal Articlegold Open Access

Authors

Ying Li · Sun Yat-sen University

Zheng-Yi Luo · Sun Yat-sen University

Yu-Ying Hu · Sun Yat-sen University

Yue-Wei Bi · Southern Medical University

Jian‐Ming Yang · Southern Medical University

Wen-Jun Zou · Southern Medical University

Yunlong Song ·

Abstract

Our study uncovers a key role for the gut microbiota in the regulation of autism-like social behavior by vitamin B<sub>6</sub>, dopamine, and the E/I balance in EphB6-deficient mice, and these findings suggest new strategies for understanding and treating ASD. Video abstract.

Topics & Keywords

Autism Spectrum Disorder Research Genetics and Neurodevelopmental Disorders Nerve injury and regeneration

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Microbiome

Volume 8, Issue 1, pp. 120-120

DOI: 10.1186/s40168-020-00884-z

Field-Weighted Citation Impact: 7.61