Saturated Bioisosteres of <i>ortho</i>‐Substituted Benzenes

2020199 citationsJournal Article

Authors

Svitlana V. Shishkina · State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine

Nataliya M. Voloshchuk · National University of Life and Environmental Sciences of Ukraine

Pavel K. Mykhailiuk · Taras Shevchenko National University of Kyiv

Abstract

Saturated bioisosteres of ortho-disubstituted benzenes (bicyclo[2.1.1]hexanes) were synthesized, characterized and validated. These cores were incorporated into the bioactive compounds Valsartan, Boskalid and Fluxapyroxad instead of the benzene ring. The saturated analogues showed a similar level of antifungal activity compared to that of Boskalid and Fluxapyroxad.

Topics & Keywords

Oxidative Organic Chemistry Reactions Asymmetric Synthesis and Catalysis Organic Chemistry Cycloaddition Reactions

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Angewandte Chemie International Edition

Volume 59, Issue 46, pp. 20515-20521

DOI: 10.1002/anie.202004183

Field-Weighted Citation Impact: 7.23