Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity

2020228 citationsJournal Articlebronze Open Access

Authors

Barnaby Edward Young · Nanyang Technological University

Sean Wei Xiang Ong · Tan Tock Seng Hospital

Lisa F. P. Ng · Agency for Science, Technology and Research

Danielle E. Anderson · Duke-NUS Medical School

Wan Ni Chia · Duke-NUS Medical School

Po Ying Chia · Nanyang Technological University

Li Wei Ang

Abstract

We found virus viability was associated with lower PCR Ct value in early illness. A stronger antibody response was associated with disease severity. The overactive proinflammatory immune signatures offer targets for host-directed immunotherapy, which should be evaluated in randomized controlled trials.

Topics & Keywords

SARS-CoV-2 and COVID-19 Research COVID-19 epidemiological studies COVID-19 Clinical Research Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Infectious Diseases

Volume 73, Issue 9, pp. e2932-e2942

DOI: 10.1093/cid/ciaa1280

Field-Weighted Citation Impact: 4.29