Impact of smoking behavior on clozapine blood levels – a systematic review and meta‐analysis

202097 citationsReviewhybrid Open Access

Authors

Laura McMahon · The University of Queensland

Dan Siskind · The University of Queensland

Abstract

Smoking behavior and any change in smoking behavior is associated with a substantial effect on clozapine blood levels. Reductions of clozapine dose of 30% are recommended when a patient on clozapine stops smoking. Reductions should be informed by clozapine steady-state trough levels and a close clinical risk-benefit evaluation.

Topics & Keywords

Schizophrenia research and treatment Smoking Behavior and Cessation Tryptophan and brain disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Acta Psychiatrica Scandinavica

Volume 142, Issue 6, pp. 456-466

DOI: 10.1111/acps.13228

Field-Weighted Citation Impact: 7.43