SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

2020678 citationsJournal Articlegold Open Access

Authors

Si Zhang · First Affiliated Hospital of Wenzhou Medical University

Yangyang Liu · First Affiliated Hospital of Zhengzhou University

Xiaofang Wang · First Affiliated Hospital of Zhengzhou University

Yang Li · First Affiliated Hospital of Zhengzhou University

Haishan Li · Anhui Medical University

Yuyan Wang · Shanghai Medical College of Fudan University

Mengduan Liu

Abstract

Our findings uncovered a novel function of SARS-CoV-2 on platelet activation via binding of Spike to ACE2. SARS-CoV-2-induced platelet activation may participate in thrombus formation and inflammatory responses in COVID-19 patients.

Topics & Keywords

COVID-19 Clinical Research Studies Adipokines, Inflammation, and Metabolic Diseases Inflammatory Biomarkers in Disease Prognosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Hematology & Oncology

Volume 13, Issue 1, pp. 120-120

DOI: 10.1186/s13045-020-00954-7

Field-Weighted Citation Impact: 14.75