Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance

2020196 citationsJournal Articlegold Open Access

Authors

Jiaye Liu · Erasmus MC

Pengfei Li · Erasmus MC

Ling Wang · Erasmus MC

Meng Li · Erasmus MC

Zhouhong Ge · Erasmus MC

Lisanne Noordam · Erasmus MC

Ruby Lieshout · Erasmus MC

Abstract

We successfully established murine and human 3D co-culture models and have shown robust effects of CAFs in liver cancer nurturing and treatment resistance.

Topics & Keywords

Cancer Cells and Metastasis FOXO transcription factor regulation Liver physiology and pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cellular and Molecular Gastroenterology and Hepatology

Volume 11, Issue 2, pp. 407-431

DOI: 10.1016/j.jcmgh.2020.09.003

Field-Weighted Citation Impact: 9.63