A Lateral Flow Immunoassay for Prostate‐Specific Antigen Detection Using <scp>Silica‐Coated CdSe</scp>@<scp>ZnS</scp> Quantum Dots

Protein detection technologies are important for early disease diagnosis because of their advantages over biopsy testing. Considering the diagnostic potential of prostate‐specific antigen (PSA) in prostate cancer, in this study, we present a lateral flow immunoassay (LFIA) for successful detection of PSA by using silica‐coated CdSe@ZnS quantum dots (QD@SiO 2 ). The QD@SiO 2 were synthesized using a reverse microemulsion method. The average size of the synthesized nanoparticles (NPs) was 51.76 nm, and their quantum yield (QY) was relatively high (36.5%). PSA detection was performed using LFIA on a strip. The QD@SiO 2 surface was modified by conjugating the anti‐PSA antibody to detect the PSA. At concentrations above 1.0754 ng/mL, PSA was detected using the designed LFIA system without any nonspecific binding. The proposed QD@SiO 2 has other bioapplications as well.