Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque

2020517 citationsJournal Articlegreen Open Access

Authors

Zsófia D. Drobni · Semmelweis University

Raza M. Alvi · Massachusetts General Hospital

Jana Taron · University Medical Center Freiburg

Amna Zafar · Massachusetts General Hospital

Sean Murphy · Massachusetts General Hospital

Paula Rambarat · Massachusetts General Hospital

Rayma C. Mosarla

Abstract

Cardiovascular events were higher after initiation of ICIs, potentially mediated by accelerated progression of atherosclerosis. Optimization of cardiovascular risk factors and increased awareness of cardiovascular risk before, during, and after treatment should be considered among patients on an ICI.

Topics & Keywords

Cancer Immunotherapy and Biomarkers Cancer, Stress, Anesthesia, and Immune Response Inflammatory Biomarkers in Disease Prognosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 142, Issue 24, pp. 2299-2311

DOI: 10.1161/circulationaha.120.049981

Field-Weighted Citation Impact: 22.42