CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice

202065 citationsJournal Articlegold Open Access

Authors

Matheus Silvério Mattos · Universidade Federal de Minas Gerais

Maximiliano Ruben Ferrero · Fundação Oswaldo Cruz

Lucas Kraemer · Universidade Federal de Minas Gerais

Gabriel Augusto Oliveira Lopes · Universidade Federal de Minas Gerais

Diego Carlos dos Reis · Universidade Federal de Minas Gerais

Geovanni Dantas Cassali · Universidade Federal de Minas Gerais

Fabrício Marcus Silva Oliveira

Abstract

CXCR1/2 antagonist Ladarixin offers a new strategy for therapeutic treatment of acute and chronic neutrophilic airway inflammation, even in the context of corticosteroid-insensitivity.

Topics & Keywords

Asthma and respiratory diseases Respiratory and Cough-Related Research Pediatric health and respiratory diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Immunology

Volume 11, pp. 566953-566953

DOI: 10.3389/fimmu.2020.566953

Field-Weighted Citation Impact: 4.70