Comprehensive analysis of angiogenesis-related genes and pathways in early diabetic retinopathy

202041 citationsJournal Articlegold Open Access

Authors

Chufeng Gu · Shanghai Jiao Tong University

Thashi Lhamo · People's Hospital of Shiyan

Chen Zou · Eye & ENT Hospital of Fudan University

Chuandi Zhou · Shanghai Jiao Tong University

Tong Su · Shanghai Jiao Tong University

Deji Draga · People's Hospital of Shiyan

Dawei Luo ·

Abstract

The present study analysed angiogenesis-related genes and pathways in early DR in a comprehensive and systematic manner. PIK3CB, ALDH3A1, ITGA7, FGF23, THBS1, COL1A1, MAPK13, and AIF1 may be the candidate genes to further explore the mechanisms of angiogenesis in early DR. TNF, PIK3CB, TGFB1, EDN1, MMP9, TLR4, PDGFB, MMP2, and THBS1 may be new targets for early neovascularization therapy in the future.

Topics & Keywords

Retinal Diseases and Treatments Peroxisome Proliferator-Activated Receptors Ferroptosis and cancer prognosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Medical Genomics

Volume 13, Issue 1, pp. 142-142

DOI: 10.1186/s12920-020-00799-6

Field-Weighted Citation Impact: 3.97

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