Quantification of Neurological Blood-Based Biomarkers in Critically Ill Patients With Coronavirus Disease 2019

202051 citationsJournal Articlegold Open Access

Authors

Jennifer Cooper

Sophie Stukas

Ryan L. Hoiland · University of British Columbia

Nicholas A. Fergusson · University of British Columbia

Sonny Thiara · University of British Columbia

Denise Foster · University of British Columbia

Anish R. Mitra · University of British Columbia

A. Jon Stoessl

Abstract

Plasma glial fibrillary acidic protein is two-fold higher in critically ill patients with coronavirus disease 2019 compared with ICU controls. Higher levels of glial fibrillary acidic protein, ubiquitin carboxy-terminal hydrolase L1, and neurofilament-light chain associate with delirium in patients with coronavirus disease 2019. Elevated plasma glial fibrillary acidic protein, ubiquitin carboxy-terminal hydrolase L1, and neurofilament-light chain are independent of respiratory function and peripheral cytokines.

Topics & Keywords

Intensive Care Unit Cognitive Disorders Long-Term Effects of COVID-19 Traumatic Brain Injury and Neurovascular Disturbances

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Critical Care Explorations

Volume 2, Issue 10, pp. e0238-e0238

DOI: 10.1097/cce.0000000000000238

Field-Weighted Citation Impact: 4.50