Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

2020168 citationsJournal Articlehybrid Open Access

Authors

Stephan B. Dreyer · Beatson West of Scotland Cancer Centre

Rosanna Upstill‐Goddard · University of Glasgow

Viola Paulus-Hock · Cancer Research UK Scotland Institute

Clara Paris · Université Grenoble Alpes

Eirini-Maria Lampraki · University of Glasgow

Eloïse Dray · The University of Texas Health Science Center at San Antonio

Bryan Serrels

Abstract

Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR-proficient PC and after platinum therapy.

Topics & Keywords

Pancreatic and Hepatic Oncology Research Epigenetics and DNA Methylation Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gastroenterology

Volume 160, Issue 1, pp. 362-377.e13

DOI: 10.1053/j.gastro.2020.09.043

Field-Weighted Citation Impact: 8.88