Exosomes Derived from Bone Mesenchymal Stem Cells with the Stimulation of Fe3O4 Nanoparticles and Static Magnetic Field Enhance Wound Healing Through Upregulated miR-21-5p

2020195 citationsJournal Articlegold Open Access

Authors

Di Wu · Chinese Academy of Medical Sciences & Peking Union Medical College

Lin Kang · Chinese Academy of Medical Sciences & Peking Union Medical College

Jingjing Tian · Chinese Academy of Medical Sciences & Peking Union Medical College

Yuanhao Wu · Chinese Academy of Medical Sciences & Peking Union Medical College

Jieying Liu · Chinese Academy of Medical Sciences & Peking Union Medical College

Zhengyao Li · Chinese Academy of Medical Sciences & Peking Union Medical College

Abstract

Mag-BMSC-Exos can further enhance wound healing than BMSC-Exos by improving angiogenesis and fibroblast function, and miR-21-5p upregulation in mag-BMSC-Exos might be the potential mechanism. This work offers an effective and promising protocol to improve wound healing in clinic.

Topics & Keywords

Wound Healing and Treatments Extracellular vesicles in disease Periodontal Regeneration and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: International Journal of Nanomedicine

Volume Volume 15, pp. 7979-7993

DOI: 10.2147/ijn.s275650

Field-Weighted Citation Impact: 10.36

Command Palette

&lt;p&gt;Exosomes Derived from Bone Mesenchymal Stem Cells with the Stimulation of Fe&lt;sub&gt;3&lt;/sub&gt;O&lt;sub&gt;4&lt;/sub&gt; Nanoparticles and Static Magnetic Field Enhance Wound Healing Through Upregulated miR-21-5p&lt;/p&gt;

Authors

Abstract

Topics & Keywords

UN Sustainable Development Goals

Publication Details

<p>Exosomes Derived from Bone Mesenchymal Stem Cells with the Stimulation of Fe<sub>3</sub>O<sub>4</sub> Nanoparticles and Static Magnetic Field Enhance Wound Healing Through Upregulated miR-21-5p</p>