Small interfering RNA for cancer treatment: overcoming hurdles in delivery

2020239 citationsReviewdiamond Open Access

Authors

Nitin B. Charbe · Pontificia Universidad Católica de Chile

Nikhil D. Amnerkar

B. Ramesh

Murtaza M. Tambuwala · University of Ulster

Hamid A. Bakshi · University of Ulster

Alaa A. A. Aljabali · Yarmouk University

Saurabh C. Khadse · Shri Vile Parle Kelavani Mandal

Rajendran Satheeshkumar

Abstract

In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.

Topics & Keywords

RNA Interference and Gene Delivery Advanced biosensing and bioanalysis techniques MicroRNA in disease regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Acta Pharmaceutica Sinica B

Volume 10, Issue 11, pp. 2075-2109

DOI: 10.1016/j.apsb.2020.10.005

Field-Weighted Citation Impact: 8.93