BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

202051 citationsJournal Articlebronze Open Access

Authors

Arun Padmanabhan · Gladstone Institutes

Michael Alexanian · Gladstone Institutes

Ricardo Linares-Saldana · Regenerative Medicine Institute

Bárbara González‐Terán · Gladstone Institutes

Gaia Andreoletti

Yu Huang · Gladstone Institutes

Andrew J. Connolly · University of California, San Francisco

Abstract

These results highlight a novel role for a BRD4-GATA4 module in cooperative regulation of a cardiomyocyte-specific gene program governing bioenergetic homeostasis in the adult heart.

Topics & Keywords

Protein Degradation and Inhibitors Peptidase Inhibition and Analysis Ubiquitin and proteasome pathways

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Circulation

Volume 142, Issue 24, pp. 2338-2355

DOI: 10.1161/circulationaha.120.047753

Field-Weighted Citation Impact: 2.50