Mucosal‐Associated Invariant T Cell Dysregulation Correlates With Conjugated Bilirubin Level in Chronic HBV Infection

202055 citationsJournal Article

Authors

Yu Liu · Nanchang University

Peng Zhu · Tongji Hospital

Wei Wang · Huazhong University of Science and Technology

Xiaosheng Tan · Huazhong University of Science and Technology

Chuanqiao Liu · Wuhan Blood Center

Yingshan Chen · Chinese Academy of Sciences

Rongjuan Pei ·

Abstract

We reveal the MR1-dependent, anti-HBV potential of MAIT cells and identify conjugated bilirubin as a major factor dysregulating its frequency and function in chronic HBV-infected patients, suggesting a therapeutic target for MAIT-cell-based immunity against chronic HBV infection.

Topics & Keywords

Immune Cell Function and Interaction Hepatitis B Virus Studies Phagocytosis and Immune Regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 73, Issue 5, pp. 1671-1687

DOI: 10.1002/hep.31602

Field-Weighted Citation Impact: 2.68