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The 3.2-Å resolution structure of human mTORC2

202099 citationsJournal Articlegold Open Access

Authors

Alain Scaiola · ETH Zurich

Francesca Mangia · University of Basel

Stefan Imseng · University of Basel

Daniel Boehringer · ETH Zurich

Karolin Berneiser · University of Basel

Mitsugu Shimobayashi · University of Basel

Edward Stuttfeld · University of Basel

Abstract

The structure of mTORC2 reveals the basis of its rapamycin insensitivity and explains how mTORC2 stability controls activity.

Topics & Keywords

PI3K/AKT/mTOR signaling in cancer Protein Kinase Regulation and GTPase Signaling Receptor Mechanisms and Signaling

Publication Details

Published in: Science Advances

Volume 6, Issue 45

DOI: 10.1126/sciadv.abc1251

Field-Weighted Citation Impact: 5.01

The 3.2-Å resolution structure of human mTORC2 | Researchclopedia

Michael N. Hall · University of Basel

Nenad Ban · ETH Zurich

Timm Maier · University of Basel