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Normal micro flora in the body is created by probiotics, but in modern environmental conditions and bad economic activity in animal farming this group of microorganisms favorable and very necessary for the body is experiencing a constant and huge pressure, so the quantity and quality of each species of these microorganisms is reduced. The aim of this work is to show the effectiveness of the use of certain probiotics in the an imal farming of the Amur region. The research was conducted from 1994 to 2020 in different livestock farms of the Amur region. To assess the condition of animals, there were used generally accepted indicators and the rules of general research. The utmost attention was paid to psychoemotional condition of animals. Body weight indicators were obtained when animals were weighed. As a result, it was found out that the use of probiotics in animal farming of the Amur region showed a positive effect in all cases, but the highest efficiency is provided by “Intestevit “(94.8% of the total number of livestock survived). It is manufactured in the laboratory of the Federal State Budgetary Institution “All-Russian State Center for Quality and Standardization of Medicines for Animals and Feed» and it is based on the collection of samples of probiotics from the nomenclature of microflora characteristic of animals from different regions of the Russian Federation. In groups where animals were treated with probiotic “Intestevit”, the economic effect was higher by 23.4-25.9%.