Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction

2020271 citationsJournal Articlebronze Open Access

Authors

Virginia S. Hahn · Johns Hopkins University

Hildur Knútsdóttir · Johns Hopkins University

Xin Luo · Amgen (United States)

Kenneth Bedi · University of Pennsylvania

Kenneth B. Margulies · University of Pennsylvania

Saptarsi M. Haldar · Amgen (United States)

Marina Stolina ·

Abstract

HFpEF exhibits distinctive broad transcriptomic signatures and molecular subgroupings with particular clinical features and outcomes. The data reveal new signaling targets to consider for precision therapeutics.

Topics & Keywords

Cardiovascular Function and Risk Factors Heart Failure Treatment and Management Cardiomyopathy and Myosin Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 143, Issue 2, pp. 120-134

DOI: 10.1161/circulationaha.120.050498

Field-Weighted Citation Impact: 17.68