Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study

202035 citationsJournal Articlegold Open Access

Authors

Jiajun Liu · Midwestern University

Steven Y. C. Tong · The Royal Melbourne Hospital

Joshua S. Davis · Charles Darwin University

Nathaniel J. Rhodes · Midwestern University

Marc H. Scheetz · Midwestern University

CAMERA2 Study Group

Nick Anagostou

David Andresen

Abstract

Among patients with methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin group. Day 2 vancomycin AUC ≥470 mg·h/L was significantly associated with AKI, independent of (flu)cloxacillin receipt.

Topics & Keywords

Antimicrobial Resistance in Staphylococcus Acute Kidney Injury Research Antibiotics Pharmacokinetics and Efficacy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Open Forum Infectious Diseases

Volume 7, Issue 12, pp. ofaa538-ofaa538

DOI: 10.1093/ofid/ofaa538

Field-Weighted Citation Impact: 0.59