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The main task for the agro-industrial complex of the country and the Amur region in particular is to grow healthy livestock and obtain environmentally friendly products from it. In order to achieve these goals, special attention must be paid to the proper balanced feeding of animals, starting from the birth of the animal. In the Amur region, when harvesting their own feed, there is a shortage of normalized nutrients, which leads to a decrease in animal productivity, digestive disorders, which in turn leads to various diseases of the gastrointestinal tract and a decrease in the immune status of animals. In veterinary practice, antibiotic therapy is used to treat diseases, which along with pathogenic and conditionally pathogenic destroys useful microflora. Accumulating in the body, antibiotics cause harm not only to animals, but also carries a danger to humans. From the use of antibiotic therapy, dysbacteriosis develops, which directly affects the development of the animal as a whole. Application of probiotics to calves from the first days of life promotes early scar formation, better absorption of nutrients, which in turn leads to intensive growth and development of the young animal body. When using probiotics in animals, the intestinal microflora is normalized, thereby reducing the risk of dysbacteriosis and diarrhea, thereby improving growth, development and metabolic processes. In farms of the Amur region, the use of probiotics in feeding calves of the dairy period has not been sufficiently studied.