Analysis of cell-free DNA in a consecutive series of 13,607 routine cases for the detection of fetal chromosomal aneuploidies in a single center in Germany

202022 citationsJournal Articlehybrid Open Access

Authors

Heike Borth · Amedes Genetics (Germany)

Anna Teubert · Amedes Genetics (Germany)

Ralf Glaubitz · Amedes Genetics (Germany)

Sarah Knippenberg · Amedes Genetics (Germany)

Nargül Kutur · Amedes Genetics (Germany)

Thomas W. Winkler · Amedes Genetics (Germany)

B. Eiben ·

Abstract

The VeriSeq NIPT Solution v2 assay detected fetal chromosomal aneuploidies across a range of fetal fractions with high sensitivities and specificities observed based on known clinical outcomes, a high overall PPV, and a low failure rate.

Topics & Keywords

Prenatal Screening and Diagnostics Parvovirus B19 Infection Studies Fetal and Pediatric Neurological Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of Gynecology and Obstetrics

Volume 303, Issue 6, pp. 1407-1414

DOI: 10.1007/s00404-020-05856-0

Field-Weighted Citation Impact: 5.23