Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

Hydrogen sulfide (H₂S) was once considered to have only toxic properties, until it was discovered to be an endogenous signaling molecule. The effects of H₂S are dose dependent, with lower concentrations being beneficial and higher concentrations, cytotoxic. This scenario is especially true for the effects of H₂S on mitochondrial function, where higher concentrations of the gasotransmitter inhibit the electron transport chain, and lower concentrations stimulate bioenergetics in multiple ways. Here we review the role of H₂S in mitochondrial function and its effects on cellular physiology.