COVID-19 and Sepsis Are Associated With Different Abnormalities in Plasma Procoagulant and Fibrinolytic Activity

2020139 citationsJournal Articlegreen Open Access

Authors

Emma G. Bouck · University of North Carolina at Chapel Hill

Frederik Denorme · University of Utah

Lori A. Holle · University of North Carolina at Chapel Hill

Elizabeth A. Middelton · University of Utah

Antoinette Blair · University of Utah

Bas de Laat · Synapse (Netherlands)

Joshua D. Schiffman

Abstract

Both COVID-19 and sepsis are associated with endogenous activation of coagulation and fibrinolysis, but these diseases differently impact plasma procoagulant and fibrinolytic potential. Dysregulation of procoagulant and fibrinolytic pathways may uniquely contribute to the pathophysiology of COVID-19 and sepsis.

Topics & Keywords

COVID-19 Clinical Research Studies COVID-19 and healthcare impacts Blood properties and coagulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 41, Issue 1, pp. 401-414

DOI: 10.1161/atvbaha.120.315338

Field-Weighted Citation Impact: 2.73