Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer

2015152 citationsJournal Articlehybrid Open Access

Authors

Toni T. Seppälä · Central Finland Health Care District

Jan Böhm · Central Finland Health Care District

Marjukka Friman · Central Finland Health Care District

Laura Lahtinen · Central Finland Health Care District

Ville Väyrynen · Central Finland Health Care District

Tommi K E Liipo · Central Finland Health Care District

Ari Ristimäki

Abstract

Microsatellite instable tumours were associated with better prognosis compared with MSS. BRAF(V600E) was associated with poor prognosis unless it occurred together with MSI. The MSI/BRAF(V600E) subtype was a favourable prognostic factor compared with the MSS/BRAF wild-type subtype. BRAF(V600E) rectal tumours showed particularly poor prognosis. The MSS/BRAF(V600E) subtype was associated with increased disease-specific mortality even in stage I-II CRC.

Topics & Keywords

Genetic factors in colorectal cancer Colorectal Cancer Treatments and Studies Colorectal Cancer Screening and Detection

UN Sustainable Development Goals

No poverty

Publication Details

Published in: British Journal of Cancer

Volume 112, Issue 12, pp. 1966-1975

DOI: 10.1038/bjc.2015.160

Field-Weighted Citation Impact: 10.41