Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis

2020107 citationsJournal Articlebronze Open Access

Authors

Mark Trinder · University of British Columbia

Yanan Wang · Leiden University Medical Center

Christian M. Madsen · University of Copenhagen

Tatjana Ponomarev · British Heart Foundation

Lubos Bohunek

Brendan A. Daisely · Western University

HyeJin Julia Kong · British Heart Foundation

Abstract

Clinical genetics and humanized mouse models suggest that inhibiting CETP may preserve high-density lipoprotein levels and improve outcomes for individuals with sepsis.

Topics & Keywords

Sepsis Diagnosis and Treatment Diabetes, Cardiovascular Risks, and Lipoproteins Lipoproteins and Cardiovascular Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 143, Issue 9, pp. 921-934

DOI: 10.1161/circulationaha.120.048568

Field-Weighted Citation Impact: 8.29