Phosphorus Ligands from the Zhang Lab: Design, Asymmetric Hydrogenation, and Industrial Applications

Abstract Chiral phosphorus ligands have played a crucial role for the recent advances in asymmetric catalysis. This review summarizes chiral phosphorus ligands developed from the Laboratory of Professor Xumu Zhang in the latest 25 years. A number of iconic phosphorus ligands including bisphosphorus ligands with rigid chiral backbone such as BICP, PennPhos, TunePhos, and f ‐Binaphane, P ‐chiral bisphosphorus ligands TangPhos, Binapine, and DuanPhos, phosphine‐phosphoramidte ligand YanPhos, noncovalent interaction‐assisted ferrocenyl phosphorus ligand ZhaoPhos and WudaPhos, and tridentate ferrocenyl phosphorus ligands f ‐amphox are introduced, and their applications in asymmetric hydrogenation are emphasized.