N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

2020318 citationsJournal Articlegold Open Access

Authors

Junjie Xu · Zhejiang Lab

Zhe Wan · Zhejiang University

Minyue Tang · Women's Hospital, School of Medicine, Zhejiang University

Zhongjie Lin · Zhejiang University

Jiang Shi · Zhejiang University

Lin Ji · Zhejiang Lab

Kirill Gorshkov ·

Abstract

This work indicates a novel mechanism for maintaining sorafenib resistance and is a proof-of-concept study for targeting circRNA-SORE in sorafenib-treated HCC patients as a novel pharmaceutical intervention for advanced HCC.

Topics & Keywords

Circular RNAs in diseases RNA modifications and cancer MicroRNA in disease regulation

Publication Details

Published in: Molecular Cancer

Volume 19, Issue 1, pp. 163-163

DOI: 10.1186/s12943-020-01281-8

Field-Weighted Citation Impact: 18.53

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N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

Authors

Abstract

Topics & Keywords

Publication Details