Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma

202063 citationsJournal Article

Authors

Leticia Colyn · Universidad de Navarra

Marina Bárcena‐Varela · Universidad de Navarra

Gloria Álvarez‐Sola · Instituto de Salud Carlos III

María U. Latasa · Universidad de Navarra

Iker Uriarte · Instituto de Salud Carlos III

Eva Santamaría · Instituto de Salud Carlos III

José M. Herranz

Abstract

Dual targeting of G9a and DNMT1 with epigenetic small molecule inhibitors such as CM272 is a potential strategy to treat CCA and/or enhance the efficacy of other systemic therapies.

Topics & Keywords

Cholangiocarcinoma and Gallbladder Cancer Studies Epigenetics and DNA Methylation RNA modifications and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 73, Issue 6, pp. 2380-2396

DOI: 10.1002/hep.31642

Field-Weighted Citation Impact: 5.72