SIRT3 (Sirtuin-3) Prevents Ang II (Angiotensin II)–Induced Macrophage Metabolic Switch Improving Perivascular Adipose Tissue Function

202056 citationsJournal Article

Authors

Tong Wei · Shanghai Institute of Hypertension

Jing Gao · Shanghai Institute of Hypertension

Chenglin Huang · Shanghai Institute of Hypertension

Bei Song · Shanghai Institute of Hypertension

Mengwei Sun · General Administration of Sport of China

Weili Shen · Ruijin Hospital

Abstract

SIRT3 represents a potential therapeutic target to attenuate NLRP3-related inflammation. Pharmacological targeting of glycolytic metabolism may represent an effective therapeutic approach.

Topics & Keywords

Adipose Tissue and Metabolism Cardiovascular Disease and Adiposity Biochemical effects in animals

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 41, Issue 2, pp. 714-730

DOI: 10.1161/atvbaha.120.315337

Field-Weighted Citation Impact: 3.85