Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine

2020271 citationsJournal Articlegold Open Access

Authors

Simeng Wen · Second Hospital of Tianjin Medical University

Yulei Wei · Tianjin First Center Hospital

Chong Zen · Central South University

Wei Xiong · Central South University

Yuanjie Niu · Tianjin Medical University

Yu Zhao · WinnMed

Abstract

Collectively, the findings indicate that m6A on ncRNA NEAT1-1 takes critical role in regulating Pol II ser2 phosphorylation and may be novel specific target for bone metastasis cancer therapy and diagnosis. New complex CYCLINL1/CDK19/NEAT1-1 might provide new insight into the potential mechanism of the pathogenesis and development of bone metastatic prostate cancer.

Topics & Keywords

RNA modifications and cancer Cancer-related molecular mechanisms research Cancer-related gene regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Cancer

Volume 19, Issue 1, pp. 171-171

DOI: 10.1186/s12943-020-01293-4

Field-Weighted Citation Impact: 16.27