Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

2020192 citationsJournal Articlebronze Open Access

Authors

Maarja Andaloussi Mäe · Uppsala University

Liqun He · Uppsala University

Sofia Nordling · Uppsala University

Elisa Vázquez-Liébanas · Uppsala University

Khayrun Nahar · Uppsala University

B. Jung · Uppsala University

Xidan Li · Integrated Cardio Metabolic Centre

Abstract

By elucidating the complexity of endothelial response to pericyte deficiency at cellular resolution, our study provides insight into the importance of brain pericytes for endothelial arterio-venous zonation, angiogenic quiescence, and a limited set of BBB functions. The BBB-reinforcing role of ANGPT2 (angiopoietin 2) is paradoxical given its wider role as TIE2 (TEK receptor tyrosine kinase) receptor antagonist and may suggest a unique and context-dependent function of ANGPT2 in the brain.

Topics & Keywords

Barrier Structure and Function Studies Single-cell and spatial transcriptomics Cancer Cells and Metastasis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 128, Issue 4, pp. e46-e62

DOI: 10.1161/circresaha.120.317473

Field-Weighted Citation Impact: 9.80