The emergence of azithromycin-resistant <i>Salmonella</i> Typhi in Nepal

This is the first molecular description of Azith^R <i>S</i>. Typhi in Nepal. These organisms showed no phylogenetic link to Azith^R <i>S</i>. Typhi in Bangladesh. Our data suggest that increasing use of azithromycin may pose a strong selective pressure driving the emergence of Azith^R <i>S</i>. Typhi in South Asia. Further investigations are needed to evaluate treatment responses to azithromycin, predict evolutionary trajectories, and track the transmission of these organisms.