Aberrant Activation of Notch1 Signaling in Glomerular Endothelium Induces Albuminuria

202136 citationsJournal Articlebronze Open Access

Authors

Liqun Li · Shandong Provincial QianFoShan Hospital

Qiang Liu · Shandong Provincial QianFoShan Hospital

Tongyao Shang · Shandong Provincial QianFoShan Hospital

Wei Song · Shandong Provincial QianFoShan Hospital

Dongmei Xu · Shandong Provincial QianFoShan Hospital

Thaddeus D. Allen · Sunnybrook Health Science Centre

Xia Wang

Abstract

Our results reveal novel regulatory mechanisms whereby endothelial Notch1 signaling dictates the level of VE-cadherin through the transcription factors SNAI1 and ERG, leading to dysfunction of glomerular filtration barrier and induction of albuminuria. Graphic Abstract: A graphic abstract is available for this article.

Topics & Keywords

Kruppel-like factors research Cerebrovascular and genetic disorders Wnt/β-catenin signaling in development and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 128, Issue 5, pp. 602-618

DOI: 10.1161/circresaha.120.316970

Field-Weighted Citation Impact: 1.70