Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

2021274 citationsJournal Articlegold Open Access

Authors

German COVID-19 Omics Initiative (DeCOI) · German Center for Neurodegenerative Diseases

Anna C. Aschenbrenner · University of Bonn

Maria Mouktaroudi · National and Kapodistrian University of Athens

Benjamin Krämer · University of Bonn

Marie Oestreich · University of Bonn

Nikolaos Antonakos · University of Bonn

Melanie Nuesch-Germano

Abstract

Our study provides novel insights in the distinct molecular subgroups or phenotypes that are not simply explained by clinical parameters. We show that whole blood transcriptomes are extremely informative for COVID-19 since they capture granulocytes which are major drivers of disease severity.

Topics & Keywords

COVID-19 Clinical Research Studies SARS-CoV-2 and COVID-19 Research Inflammasome and immune disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome Medicine

Volume 13, Issue 1, pp. 7-7

DOI: 10.1186/s13073-020-00823-5

Field-Weighted Citation Impact: 16.00