Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease

2021132 citationsJournal Articlegold Open Access

Authors

Jessica Dennis · University of British Columbia

Julia Sealock · Vanderbilt University Medical Center

Péter Straub · Vanderbilt University Medical Center

Young A Lee · Broad Institute

Donald Hucks · Vanderbilt University Medical Center

Ky’Era V. Actkins · Meharry Medical College

Annika Faucon

Abstract

Polygenic risk scores can be used to identify biomarkers of complex disease in large-scale EHR-based genomic analyses, providing new avenues for discovery of novel biomarkers and deeper understanding of disease trajectories in pre-symptomatic individuals. We present two methods and associated software, QualityLab and LabWAS, to clean and analyze EHR labs at scale and perform a Lab-Wide Association Scan.

Topics & Keywords

Genetic Associations and Epidemiology Liver Disease Diagnosis and Treatment Advanced Causal Inference Techniques

Publication Details

Published in: Genome Medicine

Volume 13, Issue 1, pp. 6-6

DOI: 10.1186/s13073-020-00820-8

Field-Weighted Citation Impact: 19.22

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Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease

Authors

Abstract

Topics & Keywords

Publication Details