SJOGREN'S SYNDROME AND PRIMARY BILIARY CHOLANGITIS OVERLAP: GOOD RESPONSE TO HYDROXYCHLOROQUINE TREATMENT

Sjgren's syndrome (SS) can overlap with autoimmune diseases. The prevalence of SS in primary biliary cholangitis (PBC) is reported in 3.5 -100% of cases. Both diseases present similar clinical manifestations and are characterized by immune-mediated destruction of exocrine glands with participation of Th17 response. Ursodeoxycholic acid (UDCA) is the first-line drug for PBC and significantly reduces the likelihood of liver transplantation and death. Hydroxychloroquine (HCQ) is used for some SS manifestations, but no previous studies reported its impact on hepatic evolution in SS-PBC overlap patients.