CAR T cells in solid tumors: challenges and opportunities

2021558 citationsReviewgold Open Access

Authors

Faroogh Marofi · Tabriz University of Medical Sciences

Roza Motavalli · Tabriz University of Medical Sciences

В. А. Сафонов · V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry

Lakshmi Thangavelu · Saveetha University

Alexei Valerievich Yumashev · Sechenov University

Markov Alexander · Tyumen State Medical University

Navid Shomali

Abstract

Nowadays, identifying and defeating the mechanisms associated with CAR T cell dysfunction is crucial to establish CAR T cells that can proliferate and lyse tumor cells severely. In this review, we discuss the CAR signaling and efficacy T in solid tumors and evaluate the most significant barriers in this process and describe the most novel therapeutic methods aiming to the acquirement of the promising therapeutic outcome in non-hematologic malignancies.

Topics & Keywords

CAR-T cell therapy research Nanowire Synthesis and Applications Virus-based gene therapy research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stem Cell Research & Therapy

Volume 12, Issue 1, pp. 81-81

DOI: 10.1186/s13287-020-02128-1

Field-Weighted Citation Impact: 38.39