Cigarette smoke extract induces pyroptosis in human bronchial epithelial cells through the ROS/NLRP3/caspase-1 pathway

2021168 citationsJournal Articlehybrid Open Access

Authors

Mengyu Zhang · Qilu Hospital of Shandong University

Yingxiao Jiang · Qilu Hospital of Shandong University

Yi-Can Yang · Qilu Hospital of Shandong University

Jianyu Liu · Qilu Hospital of Shandong University

Huo Chen · Qilu Hospital of Shandong University

Xiu-Li Ji · Jining Traditional Chinese Medicine Hospital

Yi-Qing Qu

Abstract

CSE induced inflammation and contributed to pyroptosis through the ROS/NLRP3/caspase-1 pathway in 16HBE cells. The NLRP3 inflammasome participates in CSE-induced HBE cell damage and pyroptosis, which could provide new insights into COPD.

Topics & Keywords

Inflammasome and immune disorders Chronic Obstructive Pulmonary Disease (COPD) Research Heme Oxygenase-1 and Carbon Monoxide

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Life Sciences

Volume 269, pp. 119090-119090

DOI: 10.1016/j.lfs.2021.119090

Field-Weighted Citation Impact: 10.62