Genetic insight into sick sinus syndrome

202161 citationsJournal Articlebronze Open Access

Authors

Rósa B. Þórólfsdóttir · deCODE Genetics (Iceland)

Garðar Sveinbjörnsson · deCODE Genetics (Iceland)

Hildur M. Aegisdottir · deCODE Genetics (Iceland)

Stefania Benónísdóttir · deCODE Genetics (Iceland)

Lilja Stefánsdóttir · deCODE Genetics (Iceland)

Erna V. Ivarsdottir · deCODE Genetics (Iceland)

Gísli H. Halldórsson

Abstract

We report the associations of variants at six loci with SSS, including a missense variant in KRT8 that confers high risk in homozygotes and points to a mechanism specific to SSS development. Mendelian randomization supports a causal role for AF in the development of SSS.

Topics & Keywords

Respiratory and Cough-Related Research Medicine and Dermatology Studies History Botulinum Toxin and Related Neurological Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Heart Journal

Volume 42, Issue 20, pp. 1959-1971

DOI: 10.1093/eurheartj/ehaa1108

Field-Weighted Citation Impact: 7.50