Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism

2021240 citationsJournal Article

Authors

Xiaoting Sun · Karolinska Institutet

Xingkang He · Karolinska Institutet

Yin Zhang · Karolinska Institutet

Kayoko Hosaka · Karolinska Institutet

Patrik Andersson · Karolinska Institutet

Jing Wu · Karolinska Institutet

Jieyu Wu · Karolinska Institutet

Abstract

Our work provides novel mechanistic insights into understanding PDAC metastasis by the TAM-CAF interaction and targeting each of these signalling components would provide an attractive and new paradigm for treating pancreatic cancer.

Topics & Keywords

Pancreatic and Hepatic Oncology Research Phagocytosis and Immune Regulation Cancer Immunotherapy and Biomarkers

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 71, Issue 1, pp. 129-147

DOI: 10.1136/gutjnl-2020-322744

Field-Weighted Citation Impact: 16.64