Prognostic significance of esterase gene expression in multiple myeloma

202137 citationsJournal Articlehybrid Open Access

Authors

Romika Kumari · University of Helsinki

Muntasir Mamun Majumder · University of Helsinki

Juha Lievonen · Helsinki University Hospital

Raija Silvennoinen · Helsinki University Hospital

Pekka Anttila · University of Helsinki

Nina N. Nupponen · Oncopeptides (Sweden)

Fredrik Lehmann

Abstract

Esterase gene expression levels change as patients progress from NDMM to RRMM. High expression of OVCA2, PAFAH1B3, USP4 and SIAE, and low expression of PCED1B, are poor prognostic markers in MM, suggesting a role for these esterases in myeloma biology.

Topics & Keywords

Multiple Myeloma Research and Treatments Ubiquitin and proteasome pathways Drug Transport and Resistance Mechanisms

UN Sustainable Development Goals

No poverty

Publication Details

Published in: British Journal of Cancer

Volume 124, Issue 8, pp. 1428-1436

DOI: 10.1038/s41416-020-01237-1

Field-Weighted Citation Impact: 4.24