Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?

202154 citationsJournal Articlegold Open Access

Authors

Grazia Daniela Femminella · Hammersmith Hospital

Nicholas R Livingston · Hammersmith Hospital

Sanara Raza · Hammersmith Hospital

Thalia van der Doef · Hammersmith Hospital

Eleni Frangou · University of Oxford

Sharon Love · University of Oxford

Gail Busza ·

Abstract

In non-diabetic AD, peripheral insulin resistance is independently associated with reduced hippocampal glucose metabolism and with lower grey matter volume, suggesting that peripheral insulin resistance might influence AD pathology by its action on cerebral glucose metabolism and on neurodegeneration.

Topics & Keywords

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Neurological Disease Mechanisms and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s Research & Therapy

Volume 13, Issue 1, pp. 47-47

DOI: 10.1186/s13195-021-00784-w

Field-Weighted Citation Impact: 6.41