Exploring the Interactions Between Caffeic Acid and Human Serum Albumin Using Spectroscopic and Molecular Docking Techniques

In fruits, it may constitute up to 70% of the total HCAs content The relatively good bioavailability of CA makes it possible to interact with human serum albumin (HSA) in the body In a cross-over study with 4 female and 3 male healthy ileostomy subjects, 95% of the ingested caffeic acid was absorbed from the small intestine in humans CA possesses different biological activities, such as antioxidant properties due to its high radical scavenging activity, and antimutagenic, anti-inflammatory, antidepressant, antimetastatic, anticarcinogenic, HIV replication-inhibitory, and antianxiety activities Additionally, CA has been reported to induce apoptosis in cancerous cells and inhibit tumor proliferation in animal models CA