Differential Effects of Trp53 Alterations in Murine Colorectal Cancer

20216 citationsJournal Articlegold Open Access

Authors

Alexander Betzler · Heidelberg University

Lahiri Kanth Nanduri · University Hospital Carl Gustav Carus

Bárbara Hissa · Heidelberg University

Linda Blickensdörfer · Heidelberg University

Michael H. Muders · University of Bonn

Janine Roy · TU Dresden

Moritz Jesinghaus ·

Abstract

This model realistically mimics human CRC in many aspects, allows new insights into the role of TP53 in CRC, enables highly predictive preclinical studies and demonstrates the value of GEMMs in current translational cancer research and drug development.

Topics & Keywords

Genetic factors in colorectal cancer Colorectal Cancer Treatments and Studies Cancer-related Molecular Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancers

Volume 13, Issue 4, pp. 808-808

DOI: 10.3390/cancers13040808

Field-Weighted Citation Impact: 0.76