Utility of a safety switch to abrogate CD19.CAR T-cell–associated neurotoxicity

2] Although many cases of ICANS resolve with supportive measures, high-grade ICANS may result in status epilepticus, lasting neurologic deficits, cerebral edema, 6 and death. 7 Therefore, novel approaches for severe ICANS fill an urgent unmet need to enhance the use of adoptive cellular therapy.