Activation of thyroid hormone receptor‐β improved disease activity and metabolism independent of body weight in a mouse model of non‐alcoholic steatohepatitis and fibrosis

2021119 citationsJournal Articlehybrid Open Access

Authors

Aimo Kannt · Goethe University Frankfurt

Paulus Wohlfart · Sanofi (Germany)

Andreas Nygaard Madsen · Gubra (Denmark)

Sanne Skovgård Veidal · Gubra (Denmark)

Michael Feigh · Gubra (Denmark)

Dieter Schmoll · Sanofi (Germany)

Abstract

Our model robustly reflected clinical observations of body weight-independent improvements in systemic and hepatic metabolism including anti-steatotic activity.

Topics & Keywords

Liver Disease Diagnosis and Treatment Diet, Metabolism, and Disease Growth Hormone and Insulin-like Growth Factors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 178, Issue 12, pp. 2412-2423

DOI: 10.1111/bph.15427

Field-Weighted Citation Impact: 11.30