Gene Sequencing for Pathogenic Variants Among Adults With Breast and Ovarian Cancer in the Caribbean

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Authors

Sophia George · University of Miami

Talia Donenberg · Sylvester Comprehensive Cancer Center

Cheryl Alexis · University of the West Indies

Vincent DeGennaro

Hedda Dyer · Ross University School of Medicine

Sook Yin · University College of the Cayman Islands

Jameel Ali

Raleigh Butler

Abstract

In this study, among Caribbean-born individuals with breast and ovarian cancer, 1 in 7 had hereditary breast and ovarian cancer. The proportion of hereditary breast and ovarian cancer varied by island and ranged from 23% in the Bahamas to 4.9% in Jamaica. Each island had a distinctive set of variants.

Topics & Keywords

BRCA gene mutations in cancer Genetic factors in colorectal cancer Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Network Open

Volume 4, Issue 3, pp. e210307-e210307

DOI: 10.1001/jamanetworkopen.2021.0307

Field-Weighted Citation Impact: 9.52